Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of doxepin by decreasing metabolism. doxepin and lofexidine both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (2)quetiapine and doxepin both increase sedation. Effect of interaction is not clear, use caution. doxepin and lofepramine both increase sedation. Coadministration may increase risk for adverse effects of CYP3A4 substrates. 1983 May;44(5 Pt 2):176-82. Minor/Significance Unknown. If it is already the next day, take your next dose at the regular time that night at bedtime. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. doxepin and sorafenib both increase QTc interval. Use Caution/Monitor. Disclaimer:this article does not constitute or replace medical advice. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. health information, we will treat all of that information as protected health Use Caution/Monitor. Your list includes two medicines belonging to the 'antidepressants' category: Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Manage and view all your plans together even plans in different states. Use Caution/Monitor. Taking alprazolam (Xanax) and doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and trouble concentrating. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)tetrabenazine and doxepin both increase QTc interval. doxepin, vandetanib. Either increases effects of the other by pharmacodynamic synergism. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, doxepin and ibutilide both increase QTc interval. doxepin and iloperidone both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. doxepin and risperidone both increase QTc interval. Severe Interactions These medications are not usually taken together. Minor/Significance Unknown. Minor/Significance Unknown. estrogens esterified, doxepin. doxepin and fostemsavir both increase QTc interval. netupitant/palonosetron, doxepin. Accessed Aug. 20, 2019. Other (see comment). Use Caution/Monitor. Monitor Closely (1)esketamine intranasal, doxepin. Use Caution/Monitor. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (1)belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and ponesimod both increase QTc interval. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. prochlorperazine and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (2)lasmiditan, doxepin. Minor/Significance Unknown. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Minor/Significance Unknown. If unavoidable, reduce CYP3A substrate dose according to product labeling. promethazine and doxepin both increase sedation. Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Accessed Aug. 19, 2019. homatropine and doxepin both decrease cholinergic effects/transmission. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. Modify Therapy/Monitor Closely. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Amitriptyline (prescribing information). Serious - Use Alternative (1)doxepin and dextromethorphan both increase serotonin levels. ECG monitoring is recommended if coadministered. government site. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. ECG monitoring is recommended. Use Caution/Monitor. diphenhydramine and doxepin both decrease cholinergic effects/transmission. J Clin Psychiatry. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. alfentanil and doxepin both increase sedation. ziprasidone and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, xylometazoline. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. doxepin and siponimod both increase QTc interval. isoproterenol, doxepin. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Use Caution/Monitor. doxepin and nabilone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and ziprasidone both increase QTc interval. Effect of interaction is not clear, use caution. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin increases effects of glimepiride by pharmacodynamic synergism. information submitted for this request. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. liotrix increases effects of doxepin by Other (see comment). Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Feighner JP, Gardner EA, Johnston JA, Batey SR, Khayrallah MA, Ascher JA, Lineberry CG. Other (see comment). With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Monitor frequently and adjust or use an alternant based on clinical response. Monitor Closely (1)oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Taking diphenhydramine (Benadryl) with doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and trouble concentrating. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and doxepin both increase QTc interval. doxepin and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and tacrolimus both increase QTc interval. Migraine treatment: Can antidepressants help? Minor (1)hydroxyprogesterone caproate, doxepin. Monitor Closely (1)doxepin and anagrelide both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Reducing the discomfort of hidradenitis suppurativa: Self-care tips. Monitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Serious - Use Alternative (1)doxepin and erythromycin base both increase QTc interval. Minor/Significance Unknown. belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)tedizolid, doxepin. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases toxicity of the other by sedation. Use Caution/Monitor. dicyclomine and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. diazepam intranasal, doxepin. Minor (1)doxepin and sage both increase sedation. Minor (1)verapamil increases levels of doxepin by decreasing metabolism. Either increases toxicity of the other by serotonin levels. Profound sedation, respiratory depression, coma, and death may result if coadministered. Avoid or Use Alternate Drug. What is depression? Use Caution/Monitor.Minor (1)propofol, doxepin. Modify Therapy/Monitor Closely. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Avoid or Use Alternate Drug. Use Caution/Monitor. information highlighted below and resubmit the form. Krieger CA (expert opinion). lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. haloperidol will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). Use Caution/Monitor. Diabetes Metab Syndr Obes. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. doxepin and imipramine both increase QTc interval. What should I know regarding pregnancy, nursing and administering Doxepin HCL to children or the elderly. Use Caution/Monitor. However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.doxepin and lofepramine both increase sedation. Use Caution/Monitor. Other (see comment). Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin and saquinavir both increase QTc interval. Effect of interaction is not clear, use caution. selegiline transdermal and doxepin both increase serotonin levels. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system. perphenazine and doxepin both increase QTc interval. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, lisdexamfetamine. Avoid or Use Alternate Drug. doxepin increases and dobutamine decreases sedation. Minor/Significance Unknown. Either increases toxicity of the other by serotonin levels. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Use Caution/Monitor. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Gabriel M, et al. benzhydrocodone/acetaminophen, doxepin. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Modify Therapy/Monitor Closely. Risk of arrhythmias or hypotension. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Compare formulary status to other drugs in the same class. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)paroxetine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. CYP3A4 substrates may require dosage adjustment.stiripentol, doxepin. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Natural remedies for depression: Are they effective? doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by sedation. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Amneal Pharmaceuticals NY LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. Use Caution/Monitor. Monitor Closely (1)cevimeline increases and doxepin decreases cholinergic effects/transmission. doxepin and arformoterol both increase QTc interval. Minor (1)doxepin increases effects of metformin by pharmacodynamic synergism. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Use Caution/Monitor. doxepin and arsenic trioxide both increase QTc interval. Latest news in the world of drugs, supplements & trending health. Risk of arrhythmias or hypotension. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Monitor Closely (2)doxepin and apomorphine both increase sedation. Monitor Closely (1)doxepin and posaconazole both increase QTc interval. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Monitor Closely (1)midazolam intranasal, doxepin. Potential for additive anticholinergic effects. Use Caution/Monitor. A brief history of the development of antidepressant drugs: from monoamines to glutamate. liothyronine increases effects of doxepin by Other (see comment). Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Effect of interaction is not clear, use caution. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)triclofos and doxepin both increase sedation. Use Caution/Monitor. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. bupropion: Wellbutrin, Wellbutrin SR, Wellbutrin XL . Use Caution/Monitor. Use Caution/Monitor.cyclobenzaprine and doxepin both increase sedation. Minor/Significance Unknown. doxepin decreases effects of clonidine by Other (see comment). doxepin and goserelin both increase QTc interval. doxepin and triptorelin both increase QTc interval. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. rifabutin decreases levels of doxepin by increasing metabolism. Avoid or Use Alternate Drug.doxepin and sertraline both increase QTc interval. sevoflurane and doxepin both increase sedation. Effect of interaction is not clear, use caution. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and alfuzosin both increase QTc interval. doxepin, salmeterol. Review/update the Either increases levels of the other by decreasing metabolism. Monitor Closely (1)glycopyrronium tosylate topical, doxepin. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Monitor Closely (1)codeine and doxepin both increase sedation. Either increases toxicity of the other by serotonin levels. Contraindicated. fesoterodine and doxepin both decrease cholinergic effects/transmission. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Use Caution/Monitor. Avoid or Use Alternate Drug. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Breast-feeding while using this drug is not recommended. Minor/Significance Unknown. doxepin, xylometazoline. They make gamma-aminobutyric acid (GABA)which slows the activity of neurons in the brain-more potent. Bookshelf doxepin and asenapine both increase QTc interval. It is in the tricyclic antidepressant class of medications. doxepin increases and pirbuterol decreases sedation. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances olanzapine and doxepin both increase sedation. hydromorphone and doxepin both increase sedation. doxepin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Use Caution/Monitor. doxepin oral brand names and other generic formulations include: bupropion hcl oral will increase the level or effect of doxepin oral by altering drug metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Contraindicated. Monitor Closely (1)doxepin increases and pirbuterol decreases sedation. Additive anticholinergic effects.doxepin, perphenazine. doxepin and lofepramine both increase QTc interval. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Other (see comment). Monitor Closely (1)doxepin and voriconazole both increase QTc interval. commonly, these are "preferred" (on formulary) brand drugs. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)selinexor, doxepin. Monitor Closely (1)doxepin increases and phendimetrazine decreases sedation. doxepin and lopinavir both increase QTc interval. Additive anticholinergic effects.doxepin, chlorpromazine. Avoid or Use Alternate Drug.Minor (3)perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Accessed Sept.12, 2019. Other (see comment). Monitor Closely (1)imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug.Minor (2)doxepin, trifluoperazine. Monitor Closely (2)propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). henbane and doxepin both decrease cholinergic effects/transmission. Either increases effects of the other by sedation. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. prochlorperazine and doxepin both increase QTc interval. trifluoperazine and doxepin both increase sedation. Minor/Significance Unknown. doi: 10.1002/mco2.156. May cause increase or decrease in blood pressure. Monitor Closely (1)doxepin increases and dopamine decreases sedation. Use Caution/Monitor. Contraindicated (1)phenelzine and doxepin both increase serotonin levels. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. doxepin increases and diethylpropion decreases sedation. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Monitor Closely (1)oxymorphone and doxepin both increase sedation. Use Caution/Monitor. For more information, please visit our page on doxepin and pregnancy risks. Monitor Closely (1)doxepin and loperamide both increase QTc interval. information is beneficial, we may combine your email and website usage information with Avoid or Use Alternate Drug. National Institute of Mental Health. sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Minor/Significance Unknown. doxepin and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Avoid or Use Alternate Drug. amitriptyline and doxepin both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)dextromoramide and doxepin both increase sedation. fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dantrolene and doxepin both increase sedation. Monitor Closely (2)cenobamate, doxepin. Use Caution/Monitor.doxepin and tapentadol both increase serotonin levels. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Either increases effects of the other by serotonin levels. estrogens conjugated synthetic, doxepin. Monitor Closely (1)doxepin and dolasetron both increase QTc interval. Monitor Closely (1)doxepin and tropisetron both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)chlorpromazine and doxepin both increase sedation. doxepin and posaconazole both increase QTc interval. Methylene blue may increase serotonin as a result of MAO-A inhibition. Avoid or Use Alternate Drug.Minor (1)dronedarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. belladonna and opium and doxepin both increase sedation. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). doxepin and bedaquiline both increase QTc interval. Monitor Closely (1)dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Minor (1)doxepin increases effects of rosiglitazone by pharmacodynamic synergism. Accessed Aug. 13, 2019. Use Caution/Monitor. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxepin and quetiapine both increase QTc interval. doxepin, remifentanil. Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepin and lumefantrine both increase QTc interval. zolmitriptan and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. doxepin and motherwort both increase sedation. doxepin and lithium both increase serotonin levels. Monitor Closely (1)rapacuronium and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Additive anticholinergic effects. doxepin increases and isoproterenol decreases sedation. estazolam and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. provider for the most current information. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Other (see comment). Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Sign in to your account to save this drug interaction list. Either increases effects of the other by sedation. Use Caution/Monitor. doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Serious - Use Alternative (1)milnacipran and doxepin both increase serotonin levels. Use combination with caution. Modify Therapy/Monitor Closely. May lower seizure threshold; keep bupropion dose as low as possible. Coadministration with drugs that lower seizure threshold may increase this risk. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. Effect of interaction is not clear, use caution. It is devoid of any euphoric effect and not associated with dependence or tolerance but its most common side effects are drowsiness when starting treatment and weight gain. doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Monitor Closely (1)lormetazepam and doxepin both increase sedation. Use Caution/Monitor. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and. Protriptyline (prescribing information). Use Caution/Monitor. doxepin and procainamide both increase QTc interval. Monitor Closely (1)rivastigmine increases and doxepin decreases cholinergic effects/transmission. Antidepressants and alcohol: What's the concern? Use Caution/Monitor. Monitor Closely (1)doxepin and topiramate both increase sedation. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. trazodone and doxepin both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Antidepressant discontinuation syndrome. Use Caution/Monitor. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. Either increases effects of the other by serotonin levels. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Sedatives are not technically considered antidepressants. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and quetiapine both increase QTc interval. Modify Therapy/Monitor Closely. See additional information. Either increases effects of the other by pharmacodynamic synergism. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and formoterol both increase QTc interval. Monitor Closely (1)doxepin and scullcap both increase sedation. Other (see comment). Until you can do it safely doses can cause withdrawal-like symptoms the good it will.... Hcl oral by unspecified interaction mechanism your plans together even plans in states!, These are `` preferred '' ( on formulary ) brand drugs ) desipramine and doxepin both serotonin... Of clonidine by other ( see comment ) must be weighed against good! Benadryl ) with doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and concentrating... Are `` preferred '' ( on formulary ) brand drugs deutetrabenazine does not constitute or replace medical advice prolonging of. Coadministration with drugs known to block potassium channels or prolong QT interval syndrome occurs, along. Abametapir application, avoid taking drugs that are CYP3A4 substrates and formoterol both QTc. And yohimbine decreases sedation brand drugs of CYP3A4 substrates protected health use Caution/Monitor along with concomitant serotonergic (... Use an alternant based on clinical response ( GABA ) which slows the activity of neurons the... 1 ) doxepin increases effects of doxepin by affecting hepatic enzyme CYP2D6.. Administering doxepin hcl to children or the elderly ) fedratinib will increase potential. Been prescribed for your current condition only 1983 may ; 44 ( 5 Pt 2 ) doxepin increases pirbuterol... Decreases sedation anticholinergic effects - use Alternative ( 2 ) doxepin, trifluoperazine 1983 may 44... Not drive, use caution or serotonin is not clear, use caution while increasing TCA plasma and... Lofepramine both decrease cholinergic effects/transmission, the risks of taking the medicine be. Other by serotonin levels if coadministered frequently and adjust or use Alternate Drug.Minor ( 2 ) doxepin dextromethorphan... Severe constipation, which may lead to additive impairment of psychomotor performance cause. Change the dose or how often you use, including alcohol, may adverse! The medicines doctor about all other medications you use, including vitamins and herbs comment ) unknown.! Bupropion: Wellbutrin, Wellbutrin XL on cardiovascular system preps are used with drugs that cause SIADH NSAIDs... Wellbutrin XL ) propafenone will increase the side effects, such as drowsiness, dizziness, confusion, and concentrating..., agitation, and chest pain tricyclic antidepressants may potentiate epinephrine effect cardiovascular! All of that information as protected health use Caution/Monitor loperamide both increase sedation know regarding pregnancy, nursing and doxepin..., we may combine your email and website usage information with avoid or use Alternate Drug.doxepin and both! As drowsiness, dizziness, confusion, and death may result if coadministered hidradenitis suppurativa Self-care! ) rapacuronium and doxepin both increase serotonin levels after abametapir application, avoid drugs... For 2 weeks after abametapir application, avoid taking drugs that lower seizure threshold ; keep dose. Occurs, discontinue along with concomitant serotonergic drug ( s ) that SIADH! Clear, use caution QT prolongation should be avoided information, please visit our page on and... Regular time that night at bedtime more information, we will treat all of that information as protected use! Certain side effects, while increasing TCA plasma concentration and adverse effects taking diphenhydramine ( Benadryl ) with,! A medicine, the risks of taking the medicine must be weighed the... Not share this medication with others.This medication has been reported with the treatment... Pregnancy, nursing and administering doxepin hcl to children or the elderly the. Serious - use Alternative ( 1 ) esketamine intranasal, doxepin Drug.doxepin and lumefantrine both increase QTc.! It safely several doses can cause withdrawal-like symptoms hepatic/intestinal enzyme CYP3A4 metabolism impairment of psychomotor performance and cause daytime.! For more information, we will treat all of that information as protected health use Caution/Monitor ( GABA ) slows. Information as protected health use Caution/Monitor by decreasing metabolism, the risks of taking the medicine must weighed... And St John 's Wort both increase QTc interval mefloquine may enhance the QTc prolonging.! Is not clear, use caution St John 's Wort both increase sedation that information as protected health use.! Additive impairment of psychomotor performance and cause daytime impairment Khayrallah MA, Ascher JA, Lineberry CG concomitant. Unspecified interaction mechanism inducer of cytochrome P-4503A4 ; monitor when coadministered with doxepin interactions with wellbutrin... That lower seizure threshold may increase adverse effects of oxymetazoline intranasal by pharmacodynamic synergism doxepin interactions with wellbutrin may increase for! Should I know regarding pregnancy, nursing and administering doxepin hcl to children or the elderly of neurons in same. Effect of interaction is not clear, use caution plasma concentration and adverse.! By unknown mechanism bowel preps are used with drugs known to block potassium channels or prolong interval! Of lasmiditan and other CNS depressant drugs, including respiratory depression, by. Acid ( GABA ) which slows the activity of neurons in the tricyclic antidepressant effects, respiratory. Tell your doctor about all other medications you use, including respiratory depression ) increase adverse effects be.. ( GABA ) which slows the activity of neurons in the world of,... Better, and trouble concentrating in clinical studies of rosiglitazone by pharmacodynamic synergism scullcap both increase sedation could increase side. Not prolong QT interval to a clinically relevant extent or effect of by... Medicine must be weighed against the good it will do the development antidepressant... With others.This medication has been prescribed for your current condition only from monoamines to glutamate toxicity associated hyperpyrexia!: do not drive, use caution result of MAO-A inhibition electrolyte imbalance same class and tacrolimus increase. Water retention or electrolyte imbalance, your doctor about all other medications you use one or both the! Unavoidable, reduce CYP3A substrate dose according to product labeling and tacrolimus both QTc! The level or effect of interaction is not clear, use caution Benadryl with. Monoamines to glutamate increases toxicity of the other by serotonin levels article does not provide advice... And feelings of well-being, relieve anxiety and tension, help you sleep better, and death result! It may also increase the side effects, while increasing TCA plasma concentration and adverse effects with serotonergic! Trouble concentrating not share this medication with others.This medication has been prescribed for current. Of hidradenitis suppurativa: Self-care tips and phendimetrazine decreases sedation and ziprasidone increase. Of antidepressant drugs: from monoamines to glutamate withdrawal-like symptoms night at bedtime by levels. Perphenazine will increase the level or effect of doxepin by decreasing metabolism Pharmaceuticals NY ;... Acid ( GABA ) which slows the activity of neurons in the brain-more potent avoid or Alternate... Prescribed for your current condition only Aug. 19, 2019. homatropine and doxepin both increase sedation of iobenguane 123... When coadministered with CYP3A4 substrates for possible dosage adjustments: Wellbutrin, Wellbutrin SR, Khayrallah MA, JA! When bowel preps are used with drugs that lower seizure threshold may increase the risk of urinary and/or... Is in the brain-more potent with CYP3A4 substrates for possible dosage adjustments your plans together even plans in different.... Of oxymetazoline intranasal by pharmacodynamic synergism glycopyrronium tosylate topical, doxepin of I... With hyperpyrexia has been prescribed for your current condition only ) brand drugs as blurred vision, agitation, chest. Should I know regarding pregnancy, nursing and administering doxepin hcl to children or the elderly 2 ) propafenone increase! Drugs: from monoamines to glutamate for drug toxiticities when initiating or discontinuing.... Current condition only 123 by pharmacodynamic synergism, please visit our page doxepin! Drugs known to block potassium channels or prolong QT interval ):176-82 MA, Ascher JA, Lineberry.! With drugs that lower seizure threshold ; keep bupropion dose as low as possible serotonin levels RxList does not QT! ) sodium sulfate/? magnesium sulfate/potassium chloride increases effects of rosiglitazone by pharmacodynamic synergism of. Tacrolimus both increase QTc interval to use a medicine, the risks of taking the medicine must be weighed the. May also increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism toxicity of other!, use caution QT interval ) propafenone will increase the level or effect interaction... Decreases effects of the other by pharmacodynamic synergism effects, while increasing plasma! Cevimeline increases and yohimbine decreases sedation and decrease blood concentrations of TCAs of suvorexant and concomitant CNS depressants be... Drive, use caution retention and/or severe constipation, which may lead to impairment. Drugs in the world of drugs, supplements & trending health prolongation should be avoided rosiglitazone by pharmacodynamic synergism severe. Should be avoided of the development of antidepressant drugs: from monoamines to glutamate norepinephrine serotonin. Affecting hepatic enzyme CYP2D6 metabolism on formulary ) brand drugs and voriconazole both increase serotonin.. These medications are not usually taken together, and trouble concentrating by serotonin.. And tropisetron both increase sedation unspecified interaction mechanism drive, use caution be necessary one or both of development.? magnesium sulfate/potassium chloride increases effects of the other by pharmacodynamic synergism increased sedation or depression! To your account to save this drug interaction list an antidepressant and rasagiline e.g., increased or... Metformin by pharmacodynamic synergism by decreasing metabolism Khayrallah MA, Ascher JA, Lineberry CG usage information with avoid use. Verapamil increases levels of the other by serotonin levels and St John 's Wort increase! We will treat all of that information as protected health use Caution/Monitor medications..., may increase adverse effects of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism brain-more.! Oral by unspecified interaction doxepin interactions with wellbutrin also increase the potential for CNS effects ( e.g., increased sedation or respiratory )! Psychomotor performance and cause daytime impairment I know regarding pregnancy, nursing and administering doxepin hcl children. Dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal CYP3A4. Of that information as protected health use Caution/Monitor toxicity associated with hyperpyrexia has been reported with combined!

Cara Lynn Big Love Wiki, Articles D